APF is the first supplement for horses formulated to provide the unique benefits of adaptogenic herbs. Developed by an equine veterinarian, APF provides advanced nutritional protection against the negative effects of stress by supporting immune function, increasing inter-cellular metabolism, stabilizing energy regulation and improving digestive function. Developed by an equine veterinarian, APF provides advanced nutritional protection against the negative effects of stress by supporting immune function, increasing inter-cellular metabolism, stabilizing energy regulation and improving digestive function. APF has been used very successfully with the prescription medication pergolide and dietary controls to manage insulin resistance and its associated laminitis. Pergolide side effects, including loss of appetite and depression, have been noted frequently with increasing dosages necessary to control Cushings disease. Horses receiving APF showed a marked increased in energy levels, appetite, a reduction of fat in the crest and over the croup, as well as an improvement in laminitis pain. APF also demonstrated significant immuno-modulatory effects in trials conducted at a major university. This benefit is especially important in view of the immuno-suppression associated with Cushings disease. APF also has a protein sparing or anti-catabolic effect, helping to maintain skeletal muscle and utilize fat as an energy source. Horses being treated for Equine Cushings disease may benefit with a daily serving of 1 to 2 mls per 250 lbs. This amount may be given twice daily as recommended by your treating veterinarian.