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Zycortal (Desoxycorticosterone Pivalate) Injectable Suspension 25 mg/ml 4ml Vial

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Zycortal (Desoxycorticosterone Pivalate) Injectable Suspension 25 mg/ml 4ml Vial

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$179.95
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Description

For dogs with Addison's disease, Zycortal suspension is an injectable replacement therapy. Zycortal is given subcutaneously in dogs with mineralocorticoid deficiency with primary hypoadrenocorticism.

For subcutaneous use in dogs only.
Mineralocorticoid.

ZYCORTAL Suspension is a white aqueous suspension. Each milliliter contains 25 mg of desoxycorticosterone pivalate. Inactive ingredients are 10.5 mg methylcellulose, 3 mg sodium carboxymethylcellulose, 1 mg polysorbate 60, 8 mg sodium chloride, 1 mg chlorocresol and water for injection (to 100%).

DOSAGE AND ADMINISTRATION: Prior to each use, thoroughly shake the vial to resuspend the product.


ZYCORTAL Suspension replaces the mineralocorticoid hormones only. Dogs with combined glucocorticoid and mineralocorticoid deficiency should also be treated with prednisone or prednisolone at an initial dosage of 0.2-0.4 mg/kg/day (0.1-0.2 mg/lb/day).


ZYCORTAL Suspension is intended for long-term administration at intervals and doses dependent upon individual response. Tailor the dose of ZYCORTAL Suspension and the concurrently administered glucocorticoid replacement therapy to the individual dog based on clinical response and normalization of Na+ and K+ concentrations.


Initial dose of ZYCORTAL Suspension: The initial dose is 2.2 mg/kg (1 mg/lb) body weight, administered by subcutaneous injection.


Interim monitoring visit: Re-evaluate the dog and measure the serum sodium/potassium ratio (Na+/K+ ratio) approximately 10 days after the first dose, which is the time to maximum concentration (Tmax ) of desoxycorticosterone (see CLINICAL PHARMACOLOGY). If the dog’s clinical signs have worsened or not resolved, adjust the dose of prednisone/prednisolone and/or investigate other causes of the clinical signs.


Second dose of ZYCORTAL Suspension: At approximately 25 days after the first dose, re-evaluate the dog and repeat the Na+/K+ ratio.
  • If the dog is both clinically normal and has a normal Na+/K+ ratio on Day 25, adjust the dose based on the Day 10 Na+/K+ ratio using the guidelines in Table 1, below.
  • If the dog is clinically normal and has a Na+/K+ ratio > 32 on Day 25, either adjust the dose based on the Day 10 Na+/K+ ratio according to Table 1 or delay the dose (see Prolonging the dosing interval).
  • If the dog is either not clinically normal or if the Na+/K+ ratio is abnormal on Day 25, adjust the dose of prednisone/prednisolone or ZYCORTAL Suspension (see Subsequent doses and long-term management).

RX - Prescription Required


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